Nkarta is a publicly traded (Nasdaq symbol NKTX), South San Francisco headquartered, early-stage biopharmaceutical company focused on the discovery, development and commercialization of allogeneic, off-the-shelf engineered natural killer, or NK, cell therapies to treat cancer.Nkarta is seeking a highly motivated Supervisor, Manufacturing to join our Manufacturing team. They will lead the Manufacturing team in supporting our efforts in an exciting new area of cancer immunotherapy. This position is based out of South San Francisco, CA.

Position Summary

This person will be responsible for managing a team of cell culture manufacturing specialists in a clinical pharmaceutical environment. In this role you will report to the Director of Manufacturing.

Reports to Director Manufacturing

Location South San Francisco

Responsibilities

Requirements

• Bachelor’s Degree in scientific discipline or diploma with relevant experience

· A minimum of 5-7 years of experience in cGMP biological manufacturing. Cell Therapy manufacturing or other gene therapy experience is highly preferred.

· A minimum of 2-4 years of leadership experience is preferred.

· Advanced experience working with single-use bioreactors, aseptic operations, equipment, and cell culture, is highly preferred.

· Advanced efficiency working in a Biological Safety Cabinet (BSC).

· Demonstrated ability working with incubators, pipettes, and micropipettes, sterile tube welders, sterile tube sealers, and cell counting machines.

· Experience supervising, coaching, mentoring, and developing direct reports.

· Position is expected to spend ~80% of time gowned on the Manufacturing Floor.

Working Environment

This position requires the ability to occasionally lift and/or move up to 25 pounds. Specific vision abilities for this job include close vision, depth perception, and ability to adjust focus. The common requirements of an office environment (computers, computer screens, workstations, etc.) apply when not working in or around the laboratory environment. Willing and able to travel up to 10% via car and plane a requirement.

About Nkarta

Founded in 2015 at the birthplace of biotechnology, our development pipeline of engineered NK cell therapy candidates includes two co-lead clinical programs, NKX101 and NKX019. Clinical trials for 101 are in process; 019 will begin in H2 2021. Nkarta recently announced a collaboration with CRISPR Therapeutics, a world leader in gene-based medicines, for the development and commercialization of up to three new cell therapy candidates and access to clinically validated CRISPR/Cas9 genome engineering.

Complementing our broad research and development capabilities, Nkarta has also built an extensive cell therapy manufacturing operation. We have a 2,700-square foot clinical good manufacturing practice, or cGMP, facility on-site at our primary corporate location in South San Francisco, California. We plan to start in-house manufacturing of NKX019 in 2021 and NKX101 in 2022. We are also currently designing a separate, larger cGMP facility, to supply our anticipated pivotal clinical trial and commercial needs.

• The 130+ team members describe working at Nkarta through some of the following comments. While getting better work-life balance and improving communications between groups in an early stage start up environment are two areas in which we’re working, here are real anonymous comments of why people think Nkarta is a great place to work.

• “People are always open to ideas. This company provides a safe place for its employees (covid testing, etc.)”

• “Exceptionally talented, committed, *kind* & supportive team”

• “The CEO is transparent and honest with expectations for the whole company. There is genuine care amongst the leadership team for their peers and employees. I believe this is unique.”

• “Not to sound corny, but the emphasis on people as a valuable resource is something I recognize doesn't often exist elsewhere, and it's here in ample supply, which is great.”

• “It's the first place that I've worked where the executive team truly values the employees. It's a pretty amazing thing not to hear that employees can be replaced with someone new. Institutional knowledge is understood.”

• “We have a very diverse team with executives that are friendly and accessible.”

• “Smart and dedicated colleagues. Mission to make a difference in patients lives. Empower us with tools needed to succeed. Open and transparent culture. Transparent leadership. Handling of covid and running the company was done very well.”