Senior Scientist, Biochemistry and Biophysics Job at Ikena Oncology, Inc.
About Ikena
Ikena Oncology (NASDAQ: IKNA) is a clinical-stage, targeted oncology company that discovers and develops biomarker-driven therapies for cancer patients who need life-saving treatment by understanding what drives their disease. Ikena is advancing five clinical, preclinical, and discovery programs and has a global strategic collaboration with Bristol Myers Squibb. Since its inception, Ikena has raised over $300 million from leading life sciences investors and companies that include Atlas Venture, OrbiMed, BMS, Fidelity, Omega Funds, Surveyor Capital (a Citadel company), Invus, Farallon Capital Management, BVF Partners, Cowen Healthcare Investments, Logos Capital, and HealthCor Management. Ikena priced its IPO in March 2021 and trades on the NASDAQ (Ticker: IKNA).
Summary
Ikena has an exciting new opportunity to join the Research team as a highly talented biophysicist to contribute to progressing our early discovery projects forward. You will be part of an innovative, scientifically rigorous, and fast-paced team focused on developing breakthrough cancer therapies. You will bring a sense of urgency and commitment to help Ikena Oncology reach its potential and deliver novel patient-directed therapeutics to patients.
Your Role
- You will apply your biophysical and biochemistry skills to characterize small molecule interactions with targets to drive drug discovery programs
- Hands-on design and execution of biophysical and biochemical assays to support lead generation and optimization
- Characterize protein and enzyme kinetics for discovery programs and binding kinetics of small molecule protein interactions
- Determine inhibitor MOA using a variety of techniques in-house and outsourced
- Validate small molecule hits from high-throughput screens
- Identify and partner with CROs to develop biochemical, biophysical, and enzymatic assays
- Collaborate with other Ikena teams to build translational understanding between biochemical findings and other disciplines
- Present research activities at internal and external meetings
- Additional duties and responsibilities as required
Your Background
- Ph.D. in Biochemistry, Biophysics, or similar discipline with at least 2-4 years of experience in a biotechnology or pharmaceutical company
- Demonstrated hands-on expertise in developing, troubleshooting, and running biophysical, biochemical, and enzyme assays, including SPR, NMR, native mass spectrometry, and ITC
- Experience with protein design, expression, and purification
- A passion for designing and executing lab experiments to generate impactful data and test scientific hypotheses
- Experience with automation and HTS instrumentation preferred but not required
- Skilled in data analysis and visualization (Spotfire, Vortex)
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