Research Associate, LNP Formulations Job at Flagship Pioneering, Inc.

Flagship Pioneering, Inc. Cambridge, MA 02142

The Company

FL85 is a Flagship-backed, privately held biotechnology company on a mission to transform the current approach to information molecule therapeutics to unlock their full therapeutic potential. In recent years, we have begun to experience the power of information molecules in treating historically undruggable diseases and in designing therapies with unprecedented turnaround times. FL85's platform integrates nanoparticle development with world-class informatics technologies and a novel pipeline of experimentation and discovery to drive a new generation of highly effective, therapeutically relevant information molecule therapies. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Flagship Pioneering's venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), and Editas Medicines (NASDAQ: EDIT). Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12thglobally on Fortune's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Position Summary

FL85 is seeking a highly talented, collaborative, and motivated individual to develop and optimize lipid nanoparticle (LNP) formulations. The candidate will be a key contributor to the FL85 platform by designing, producing, and characterizing novel LNP formulations for nucleic acid cargos. This is a position with vast learning opportunities in the area of LNP formulation development working in a fast-paced cross-functional team setting. The successful candidate will have a strong technical background in an R&D lab environment, as well as good communication and collaboration skills.

Key Responsibilities

  • Contribute to the design, production, and characterization of a wide variety of nucleic acid LNPs
  • Perform routine analytical testing to identify and characterize novel LNP formulations
  • Produce LNP formulations to support both internal research and partner program in vitro and in pre-clinical animal studies
  • Collaborate with scientists across the organization to advance company objectives
  • Thoroughly document results in electronic lab notebooks and present findings to cross-functional teams
  • Assist in maintaining general laboratory functionality including ordering and receiving lab supplies

Qualifications

  • BS/MS in life sciences, pharmaceutical sciences, chemical engineering, bioengineering, or related discipline with 0-2 years of academic or industrial experience
  • Experience producing and characterizing nucleic acid LNPs is strongly desired
  • Experience with high throughput screening of LNPs would be a plus
  • Experience with a variety of LNP process techniques and equipment scales would be a plus (mixers, pumping systems, TFF, etc.)
  • A strong team player with the ability to work both independently and on cross-functional teams in a fast-paced, entrepreneurial environment
  • Ability to troubleshoot complex problems and demonstrate problem-solving skills
  • Comfortable delivering against challenging commitments
  • Excellent organizational and communication skills

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.




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