Postdoctoral Associate, Innovation Chemistry

Alnylam (Nasdaq: ALNY) is delivering on a bold vision to turn scientific possibility into reality, with a robust RNA interference (RNAi) therapeutics platform. As the pioneer in RNAi and the leading RNAi therapeutics company, we have always been uncompromisingly dedicated to translating the breakthrough science into transformational medicines to help as many people as possible. Long focused on rare and genetic diseases, our scientific advances are now allowing us to bring the power of RNAi therapeutics to more prevalent diseases and as a result, we are beginning to recognize the full potential of this new class of medicines.

Alnylam is committed to its journey to become a top 5 independent, global biopharma company. We are already admired and recognized for our dedication to patients, company culture that empowers people to do their best work, track record of scientific innovation, social responsibility, and commercial excellence.

Founded in 2002, and headquartered in Cambridge, Mass., Alnylam has over 1,650 employees at work across the globe. We are seeking smart, passionate, “change the world” kind of people who are ready to say, “challenge accepted” to our mission. Thanks to the commitment of every employee globally, Alnylam is proud to have been recognized as one of Fast Company’s 2021 Best Workplaces for Innovators, a Science Magazine Top Employer three years in a row (2019-2021), a Boston Globe Top Places to Work seven years in a row (2015-2021), a Great Place to Work in Asia, Japan, Brazil, the U.K., Germany, Spain, Netherlands, Italy, France and Switzerland, Seramount’s 100 Best Companies (formerly Working Mother 100 Best Companies) and Best Companies for Dads, Bloomberg’s Gender Equality Index two years in a row (2021-2022), among others. At Alnylam, we are committed to fostering a diverse, equitable and inclusive work environment, culture, and workforce, and we support several Employee Resource Networks.

Overview:

Seeking an experienced organic/medicinal chemist/bioorganic/oligonucleotide chemist with expertise in design, synthesis, analysis of small molecules, nucleosides and oligonucleotides. The candidate should have expertise in scientific literature, database and patent search; modern analytical and separation techniques and instrumentation. Successful candidate will work in a multidisciplinary environment involving discovery and development of RNAi chemical modifications, delivery agents and conjugates.

Summary of Key Responsibilities:

• Design and synthesis of small molecules, heterocycles, lipids, carbohydrates, nucleosides and nucleotides, oligonucleotides and conjugates; knowledge in design, synthesis, analysis of drug delivery systems and conjugates for nucleic acids.
• Purification of compounds using modern separation techniques
• Analysis and characterization using modern analytical techniques (NMR, MS, HPLC, IR, etc.).
• Multitasking and multidisciplinary expertise
• Expertise in scientific data base, literature survey and patent search
• Manuscript Writing skills

Qualifications:

• PhD in Organic Chemistry or bioorganic chemistry
• 0-5 years of post-doctoral experience
• Hands on experience on separation and analytical instrumentation and scientific database search.
• Instrumentation skills, desire to learn bioassays, oligonucleotide synthesis
• If employed in the U.S., being fully vaccinated against COVID-19 as defined by the Centers for Disease Control and Prevention (CDC) is required

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.